Guitar Hero: World Tour is een spel dat draait om muziek. Met een groepje van vier personen wordt een band gevormd. Twee gitaristen, een drummer en een zanger moeten op de maat van de muziek zingen of de juiste knoppen aanslaan. Doe je dit goed, dan verdien je als groep punten. Hoe meer punten je verdient, des te populairder je band wordt. Het is in Guitar Hero: World Tour zelfs mogelijk om je eigen muziek samen te stellen.

Deze PC-versie maakt gebruik van de PlayStation 3 controllers. Hierdoor is het niet per definitie noodzakelijk om geheel nieuwe controllers aan te schaffen. Deze versie van Guitar Hero: World Tour wordt geleverd met een speciale gitaar controller!

* 311 - "Beautiful Disaster" * 30 Seconds To Mars - "The Kill" * Airbourne - "Too Much Too Young" * The Allman Brothers Band - "Ramblin' Man" * Anouk - "Good God" * The Answer - "Never Too Late" * At The Drive-In - "One Armed Scissor" * Beastie Boys - "No Sleep Till Brooklyn" * Beatsteaks - "Hail to the Freaks" * Billy Idol - "Rebel Yell" * Black Label Society - "Stillborn" * Black Rebel Motorcycle Club - "Weapon of Choice" * blink-182 - "Dammit" * Blondie - "One Way or Another" * Bob Seger & The Silver Bullet Band - "Hollywood Nights" * Bon Jovi - "Livin' On A Prayer" * Bullet For My Valentine - "Scream Aim Fire" * Coldplay - "Shiver" * Creedence Clearwater Revival - "Up Around The Bend" * The Cult - "Love Removal Machine" * Dinosaur Jr. - "Feel The Pain" * The Doors - "Love Me Two Times" * Dream Theater - "Pull Me Under" * The Eagles - "Hotel California" * The Enemy - "Aggro" * Filter - "Hey Man, Nice Shot" * Fleetwood Mac - "Go Your Own Way" * Foo Fighters - "Everlong" * The Guess Who - "American Woman" * Hush Puppies - "You're Gonna Say Yeah!" * Interpol - "Obstacle 1" * Jane's Addiction - "Mountain Song" * Jimi Hendrix - "Purple Haze (Live)" * Jimi Hendrix - "The Wind Cries Mary" * Jimmy Eat World - "The Middle" * Joe Satriani - "Satch Boogie" * Kent - "Vinternoll2" * Korn - "Freak On A Leash" * Lacuna Coil - "Our Truth" * Lenny Kravitz - "Are You Gonna Go My Way" * Linkin Park - "What I've Done" * The Living End - "Prisoner of Society" * Los Lobos - "La Bamba" * Lost Prophets - "Rooftops (A Liberation Broadcast)" * Lynyrd Skynyrd - "Sweet Home Alabama (Live)" * Mars Volta - "L'Via L'Viaquez" * MC5's Wayne Kramer - "Kick Out The Jams" * Metallica - "Trapped Under Ice" * Michael Jackson - "Beat It" * Modest Mouse - "Float On" * Motörhead - "Overkill" * Muse - "Assassin" * Negramaro - "Nuvole e Lenzuola" * Nirvana - "About a Girl (Unplugged)" * No Doubt - "Spiderwebs" * NOFX - "Soul Doubt" * Oasis - "Some Might Say" * Ozzy Osbourne - "Crazy Train" * Ozzy Osbourne - "Mr. Crowley" * Paramore - "Misery Business" * Pat Benatar - "Heartbreaker" * R.E.M. - "The One I Love" * Radio Futura - "Escuela De Calor" * Rise Against - "Re-Education Through Labor" * Sex Pistols - "Pretty Vacant" * Silversun Pickups - "Lazy Eye" * Smashing Pumpkins - "Today" * Steely Dan - "Do It Again" * Steve Miller Band - "The Joker" * Sting - "Demolition Man (Live)" * The Stone Roses - "Love Spreads" * Stuck In The Sound - "Toy Boy" * Sublime - "Santeria" * Survivor - "Eye of the Tiger" * System of a Down - "B.Y.O.B." * Ted Nugent - "Stranglehold" * Ted Nugent's Original Guitar Duel Recording * Tokio Hotel - "Monsoon" * Tool - "Parabola" * Tool - "Schism" * Tool - "Vicarious" * Trust - "Antisocial" * Van Halen - "Hot For Teacher" * Willie Nelson - "On The Road Again" * Wings - "Band on the Run" * Zakk Wylde's Original Guitar Duel Recording